منابع مشابه
Clinical efficacy of intramuscular vaccinia immune globulin: a literature review.
BACKGROUND Numerous literature reports describe clinical efficacy of intramuscular vaccinia immune globulin (VIG) for complications of smallpox vaccination, prophylaxis of individuals with contraindications to vaccination, and prevention of smallpox among close contacts of patients with smallpox. METHODS We reviewed the literature regarding VIG treatment and prophylaxis of smallpox vaccine co...
متن کاملBiological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection.
The biological activity of a new intravenous (i.v.) preparation of human vaccinia immune globulin (VIGIV) was evaluated in two mouse models of vaccinia virus (VV) infection. In a mouse tail lesion model, female CD-1 mice were inoculated i.v. with 7 x 10(4) PFU of VV to produce >10 lesions per tail 8 days later. In a mouse lethality model, female severe combined immunodeficient (SCID) mice were ...
متن کاملSafety and pharmacokinetic evaluation of intravenous vaccinia immune globulin in healthy volunteers.
BACKGROUND Vaccinia immune globulin (VIG) administered via the intramuscular route has historically been used for the treatment of complications of smallpox vaccination. Intravenous formulations of VIG are required to improve tolerability and pharmacokinetic profile. METHODS We conducted 2 separate studies to evaluate the feasibility of administration of an intravenous formulation of antivacc...
متن کاملVaccinia immune globulin ameliorates eczema vaccinatum in a murine model of atopic dermatitis
Supplemental Figure Legends 182 Figure S1. Experimental design of VIG treatment using a murine model of EV. Mice 183 were EC sensitized with OVA or saline for 7 weeks followed by inoculation of 10 7 plaque 184 forming units/mouse by skin scarification. Mice were sacrificed after 7 days of VV inoculation 185 and examined for clinical responses, viral load, serum levels of VV antibodies and cytok...
متن کاملVaccinia immune globulin: current policies, preparedness, and product safety and efficacy.
In 1980 the World Health Organization declared that smallpox was eradicated from the world, and routine smallpox vaccination was discontinued. Nevertheless, samples of the smallpox virus (variola virus) were retained for research purposes, not least because of fears that terrorist groups or rogue states might also have kept samples in order to develop a bioweapon. Variola virus represents an ef...
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ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 1970
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.44.156